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Structurally, the Leu33Pro substitution generates a Pro32Pro33 sequence, which can increase the pliability of integrin α
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Our laboratory demonstrated that SERT and αvβ3 receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβ3 in midbrain synapses. Preceding research advise that in platelets, the Affiliation of SERT with activated αIIbβthree integrins, and its localization to adhesion complexes, are correlated with increased uptake exercise (Carneiro et al.
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three heads. Actually, our findings are per the Pro32Pro33 mutation retaining the ligand-binding area during the shut conformation whilst modifying the transmembrane domains, thus maximizing talin association Along with the β
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To higher realize the molecular mechanisms by which this sequence variation modifies platelet functionality, we made transgenic knockin mice expressing a Pro32Pro33 integrin β
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